• Activated dendritic cells and monocytes in HIV immunological nonresponders: HIV-induced interferon-inducible protein-10 correlates with low future CD4+ recovery 

      Stiksrud, Birgitte; Aass, Hans Christian Dalsbotten; Lorvik, Kristina Berg; Ueland, Thor; Trøseid, Marius; Dyrhol-Riise, Anne Ma (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-01)
      <i>Objective</i>: To explore monocyte and dendritic cell immune responses, and their association with future CD4<sup>+</sup> gain in treated HIV patients with suboptimal CD4<sup>+</sup> recovery.<p> <p><i>Design</i>: A cross-sectional study of HIV-infected, virally suppressed individuals on antiretroviral therapy for at least 24 months; 41 immunological nonresponders (INRs) (CD4+ cell count <400 ...
    • Association of body mass index with COVID-19 related in-hospital death 

      Bouziotis, Jason; Arvanitakis, Marianna; Preiser, Jean-Charles; Abbas, Ali; Abdukahil, Sheryl Ann; Abdulkadir, Nurul Najmee; Abe, Ryuzo; Abel, Laurent; Absil, Lara; Acharya, Subhash; Acker, Andrew; Adachi, Shingo; Adam, Elisabeth; Adrião, Diana; Al Ageel, Saleh; Ahmed, Shakeel; Ain, Quratul; Ainscough, Kate; Aisa, Tharwat; Berdal, Jan-Erik; Dudman, Susanne Gjeruldsen; Dyrhol-Riise, Anne Ma; Skeie, Linda Gail; Heggelund, Lars; Hesstvedt, Liv; Holter, Jan Cato; Jenum, Synne; Johal, Simreen Kaur; Kildal, Anders Benjamin; Bekken, Gry Klouman; Lind, Andreas; Müller, Fredrik; Muller, Karl Erik; Pettersen, Frank O.; Paulsen, Else Quist; Reikvam, Dag Henrik; Holten, Aleksander Rygh; Skogen, Vegard; Stiksrud, Birgitte; Tonby, Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-29)
      Background: Patients with extreme body mass indices (BMI) could have an increased risk of death while hospitalized for COVID-19.<p> <p>Methods: The database of the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) was used to assess the time to in-hospital death with competing-risks regression by sex and between the categories of BMI. <p>Results: Data from 12,137 ...
    • Elevated markers of gut leakage and inflammasome activation in COVID-19 patients with cardiac involvement 

      Hoel, Hedda Benedicte; Heggelund, Lars; Reikvam, Dag Henrik; Stiksrud, Birgitte; Ueland, Thor; Michelsen, Annika; Otterdal, Kari; Muller, Karl Erik; Lind, Andreas; Müller, Fredrik; Dudman, Susanne Gjeruldsen; Aukrust, Pål; Dyrhol-Riise, Anne Ma; Holter, Jan Cato; Trøseid, Marius (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-25)
      <i>Background</i> - A high proportion of COVID‐19 patients have cardiac involvement, even those without known cardiac disease. Downregulation of angiotensin converting enzyme 2 (ACE2), a receptor for SARS‐CoV‐2 and the renin‐angiotensin system, as well as inflammatory mechanisms have been suggested to play a role. ACE2 is abundant in the gut and associated with gut microbiota composition. We ...
    • Persistent pulmonary pathology after COVID-19 is associated with high viral load, weak antibody response, and high levels of matrix metalloproteinase-9 

      Lerum, Tøri Vigeland; Maltzahn, Niklas; Aukrust, Pål; Trøseid, Marius; Nezvalova-Henriksen, Katerina; Kåsine, Trine; Dyrhol-Riise, Anne Ma; Stiksrud, Birgitte; Haugli, Mette; Blomberg, Bjørn; Kittang, Bård Reiakvam; Johannessen, Asgeir; Hannula, Raisa; Aballi, Saad; Kildal, Anders Benjamin; Eiken, Ragnhild; Dahl, Tuva Børresdatter; Lund-Johansen, Fridtjof; Müller, Fredrik; Rivero, Jezabel Rodriguez; Meltzer, Carin; Einvik, Gunnar; Ueland, Thor; Olsen, Inge Christoffer; Barratt-Due, Andreas; Aaløkken, Trond Mogens; Skjønsberg, Ole Henning (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-01)
      The association between pulmonary sequelae and markers of disease severity, as well as pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19. The COPD assessment test (CAT-score), spirometry, diffusion capacity of the lungs (DL<sub>CO</sub>), and chest-CT were performed at 23 Norwegian hospitals included in the NOR-SOLIDARITY trial, an open-labelled, ...